Chronic & Non-communicable Diseases
Genetics & Omics
Reproductive Health & Menopause
Post-Doctoral Fellowships
France
Investigating the mechanisms regulating recombination during meiosis
Sexual reproduction relies on the production of gametes (sperm and egg) containing one copy of the genome. Meiotic recombination is crucial for this reduction of genomic content in gametes. Errors in recombination have been linked with infertility and developmental disorders in humans. DNA double-strand breaks (DSBs) initiate meiotic recombination. How DSB formation is regulated is currently unclear. My postdoctoral work is focused on understanding the regulation of DSB formation in mammals. We recently identified MEI4 and REC114 orthologs from higher eukaryotes, and showed that MEI4 is essential for DSB formation and fertility in mouse.
Reproduction: a complex process!
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Rajeev
KUMAR
Institution
Centre National de la Recherche Scientifique
Institut National des Sciences Biologiques (ISNB)
Country
France
Nationality
Indian
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