Medical Treatment & Drug Development
Pandemics & Infectious Diseases
Post-Doctoral Fellowships
France
Bacterial Armor Provides Protection, but Possible Treatments, Too
Back in the lab, Dr. Thibeaux will check for live Leptospira bacteria surviving inside the biofilms. This would mean that, contrary to current beliefs about the disease, Leptospira can reproduce in the environment, outside of a mammalian host. He’ll then investigate how, precisely, the biofilms work to protect the bacteria: What is their composition and how are they organized? Using advanced microscopy, he’ll even be able to observe their assembly over time.
These results will provide a thorough description of how Leptospira biofilms operate, offering new clues for evaluating the risk of leptospirosis outbreaks, as well as a much deeper understanding of the physical and chemical factors influencing the bacteria’s survival. Dr. Thibeaux’s work could indicate ways to impair their ability to generate biofilms, suggesting strategies for public health interventions that could make Leptospira vulnerable to the host’s immune system and to harsh conditions in the environment. Leptospirosis is already costly and can be life threatening; with the number of cases expected to increase to over a million per year worldwide, new approaches to treatment and prevention are badly needed.
Scientific title: Leptospires Bacterial Biofilm: An Unexplored Reservoir For Environmental Survival And Persistence Of Infectious Bacteria
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Roman
THIBEAUX
Institution
Institut Pasteur
New Caledonia
Country
France
Nationality
French
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