IBSoFACTo: Identification of Clinical, Genetic, and Bacteriological Factors Involved in the Development of Severe Bacterial Infections in Pediatrics.

Severe bacterial infections (SBIs) have become rare in countries with a high economic level but remain severe pathologies responsible for a significant morbidity and mortality in the pediatric population. There is great individual variability in the susceptibility of children to develop IBS. Indeed, when they are infected by bacteria, children will, most of the time, present a mild infection, but some will exceptionally develop an invasive bacterial infection. This variability is multifactorial, and the mechanisms at work are not yet fully understood. It has become clear for several years that genetic factors influence the susceptibility to develop IBS and its evolution. 

The project led by Nicolas Vince aims to identify clinical, genetic and bacteriological factors linked to the development of these severe infections. By better understanding the mechanisms involved, we hope to be able to prevent their consequences. The objective is to highlight rare genetic variants in genes that can affect patients' immunity, leading to failures in the corresponding protein functions, thus leading to a susceptibility to develop IBS. These defective proteins would be therapeutic avenues to improve the management of these patients.