Cellular Ageing
Ph.D
France
Ageing : a multi-scale approach
Ageing is a ubiquitous phenomenon accross species. Surprisingly, extremely different organisms exhibit similar ageing patterns, such as exponentially increasing mortality hazard with age. Based on Evolution and natural selection, we work on providing a unified framework that would account for both similarities and differences between species' mortality curves. Interestingly, not only the model reproduces experimental results for many model organisms but it also exhibits similar transitions than those observed in human mortality data and well-known diet changes experiments.
One species, different aging
Biography
After majoring in applied mathematics at the Supelec School of Engineering and simultaneously completing the "Interdisciplinary Approaches to Life Sciences" Master's programme, I had the opportunity to meet several figures in the world of science, specialising in a variety of fields (modelling, demographics, cellular biology, mathematics, etc.). I then spent several long weeks holding discussions with these researchers, with a view to preparing the PhD project that I am currently pursuing at the Jacques Monod Institute (UMR 7592) in Paris.
Research
My topic revolves around the notion of the ageing of organisms. In particular, certain experimental laws relating to population mortality have proven to be similar in a number of different organisms, from bacteria to humans. The question therefore arises as to whether global mechanisms exist that have been conserved between species and have led to the emergence of the dynamics of individual ageing. The aim of my work is to shed light on these mechanisms through the mathematical analysis of biological models that were developed for this angle of research.
AXA Fellowship
The AXA Research Fund's support has made it possible for me to pursue this innovative topic and aspire to a number of international collaboration opportunities while continuing in a spirit of interdisciplinary exchange, which is particularly important to me.
To add or modify information on this page, please contact us at the following address: community.research@axa.com
Yann
LE CUNFF
Institution
Université Paris Diderot
Université Paris VII
Country
France
Nationality
French
Related articles
Longevity, Ageing & Long-term Care
Healthy Ageing & Longevity
Genetics & Omics
Biomarkers
Cellular Ageing
Mécénat des Mutuelle
France
AGENOMICS : Using Genomic Data from Centenarians and Longitudinal Cohorts to Develop New Anti-Aging Strategies
Age-associated diseases are numerous and heterogeneous in their manifestations and evolution, and they constitute a major public health challenge. They... Read more
Jean-François
DELEUZE
CEPH - Fondation Jean Dausset
Mental Health & Neurology
Longevity, Ageing & Long-term Care
Brain Mechanisms & Psychology
Cellular Ageing
Alzheimer's Disease, Dementia & Neurodegenerative Diseases
Post-Doctoral Fellowship
Greece
Keeping our brain safe from neurodegeneration through better understanding of brain ageing mechanism
Elucidating neuronal ageing using a powerful worm model To conduct his research, Dr. Konstantinos Palikaras is using a highly malleable... Read more
Konstantinos
PALIKARAS
Institute of Molecular Biology and Biotechnology
Metabolic Health, Diabetes & Obesity
Healthy Ageing & Longevity
Cellular Ageing
Post-Doctoral Fellowship
Singapore
Fixing Inflamed “Pipes” Could Reduce or Prevent Diabetes
His methods are a departure from a common approach in diabetes research, where pancreatic cells are studied mostly in vitro,... Read more
Rafael Arrojo E
DRIGO