Health

    Women's Health

Post-Doctoral Fellowships

Switzerland

A promising new strategy to treat osteoporosis

The research project was initiated by Dr. Laura Velasquez and taken over by Dr. Alessia Perino, effective from October 1st, 2020.

Osteoporosis, the diets of young girls worldwide, obesity and related health problems among women of African origin in the UK, and the early detection of cervical cancer are also areas of research that benefited from funds from the AXA Women’s Health Fellowship.

 

Osteoporosis, a debilitating bone condition that leads to loss of bone density and bone weakening, is estimated to affect one in three women worldwide over the age of 50. This burden is likely to increase as the world’s population ages. Biologist Alessia Perino of the EPFL in Switzerland has been investigating alternative and safer treatments to estrogen replacement therapy, which has several negative side effects, and into the role bile acids play in breaking down old bone and generating new bone in its place.

 

The results from her study show a link between bone and hematopoiesis (the process in which blood cells are continuously formed and renewed) and suggest that targeting TGR5 could improve hematopoiesis by modulating bile acid-TGR5 signalling. Dr. Perino’s work could therefore help develop new therapeutics for patients with osteoporosis once the molecular mechanisms underlying the observed effects are fully understood.

Could the solution to osteoporosis be in the bile ?

Discover an article about Laura's project

ARTICLE

Laura
ALEJANDRA VELAZQUEZ VILLEGAS

Institution

École Polytechnique Fédérale de Lausanne

Country

Switzerland

Nationality

Mexican

Alessia
PERINO

Institution

École Polytechnique Fédérale de Lausanne

Country

Switzerland

Nationality

Italian

ORCID Open Researcher and Contributor ID, a unique and persistent identifier to researchers