The role of the p53 mRNA-Mdm2 interaction in controlling the DNA damage response

My research focuses on the protein p53, a key mediator of the DNA damage response which controls genome stability and cancer development. My aim is to verify the importance of the p53 mRNA (messenger RNA) – Mdm2 interaction in controlling the protein Mdm2 and p53 functions. This study holds promise to offer a viable explanation to why induction of Mdm2 by p53 in response to DNA damage leads to an actual increase in p53 activity and not to p53 inactivation.

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