The in vivo role of the RNA-binding protein SLIRP in mitochondrial function

Just as a computer needs electricity, our cells need energy, which is provided by mitochondria. Dr. Marie Lagouge is exploring the molecular machinery involved in mitochondrial production of energy, with a focus on mitochondrial genome expression, by studying the health condition of mice with disturbed machinery. Her research will improve the understanding of the mechanisms underlying many diseases linked to decline in cellular energy, such as age-related metabolic, cardiovascular and neurodegenerative disorders.